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The 15 year survival results from the Early Breast Cancer Trialists Collaborative Group EBCTCG 1 showed that a combined chemotherapy regimen of cyclophosphamide, methotrexate, and fluorouracil CMF reduces annual recurrence and death rates, a benefit that is largely independent of tamoxifen use or nonuse, estrogen receptor status, nodal status, and other tumor characteristics doxycycline treat chlamydia